Klinefelter syndrome usually occurs randomly. While no cure is known, a number of treatments may help. Klinefelter syndrome is one of the most common chromosomal disorders , occurring in one to two per 1, live male births. While XXY males can possibly be characterised based on physical characteristics, substantial variation in physical and developmental traits mean the only reliable method of positive or negative identification is karyotype testing.
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The determination of the sex of an individual, with regard to both the primary sex— i. However this may be, in order to appreciate the action of the control systems, the point of departure is that animals were primitively hermaphrodite , that during early stages of evolution every individual probably possessed both male and female gonads. Differentiation into separate sexes, each possessing male or female gonads but not both at the same time, is a device to ensure cross-fertilization of eggs, whether this is accomplished by having the two types of sexual gland mature at different stages of the growth of the individual, as in some shrimp and others, or whether by the production of two distinct types of individuals, as in most species of animals. This point of view is important because the question ceases to be how testes are caused to develop in the male organism and ovaries in the female but how, in a potentially double-sexed organism, the development of one or the other sex is suppressed. That such is the case is seen as clearly as anywhere in the human condition itself.